A promoter-associated RNA downregulates the oncogenic GLI1 transcription factor in rhabdomyosarcoma cells

DOI: 10.14800/rd.254

Authors

  • Peter G Zaphiropoulos

Abstract

Recent experimental evidence demonstrates a novel regulatory mechanism on the expression of the GLI1 oncogene, a transcriptional effector of Hedgehog signaling. This is mediated by a non-coding RNA, antisense to the GLI1 promoter, GLI1AS, which elicits negative feedback on GLI1 expression. Knockdown of GLI1AS was shown to enhance rhabdomyosarcoma tumor growth in a xenograft model, in-line with the observed increase of the expression levels of GLI1, a known proliferative/oncogenic factor in this cellular context.

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Published

2014-12-25

Issue

Vol. 1 (2014)

Section

Review