miR-92a – a key player in cardiovascular remodeling

DOI: 10.14800/rd.371

Abstract

 

Small non-coding, highly conserved microRNAs (miRs) play a crucial role in gene regulation, especially in post-transcriptional gene silencing, and are important for vascular homeostasis as well as during pathophysiological vascular remodeling processes. miR-92a is a known negative regulator of endothelial cell proliferation, angiogenesis and vascular repair. Conversely, inhibition of miR-92a improves angiogenesis in models of hind limb- or myocardial ischemia. We recently showed that inhibition of miR-92a using specific locked nucleic acid-based antimiRs accelerates the re-endothelialization process and prevents neointimal lesion formation following wire-induced injury of murine femoral arteries. Thus, miR-92a inhibitors may represent promising therapeutic tools for the treatment of vascular diseases.