miR-506: A Multitasker in Suppression of the Epithelial-to-Mesenchymal Transition

DOI: 10.14800/rd.447

Authors

  • Yan Sun, Delia Mezzanzanica, Wei Zhang

Abstract

 

miRNAs emerge as important regulators of epithelial-to-mesenchymal transition (EMT). The Best known EMT regulatory miRNAs are targeting the transcriptional repressors of E-cadherin (E-cad). We identified miR-506 as a key EMT inhibitor through directly targeting the E-cad transcriptional repressor, SNAI2. Our recent studies showed that miR-506 simultaneously suppresses vimentin and N-cad. Thus, miR-506 possesses a multitasking property in the suppression of EMT and metastasis and thus may represent a promising tool in cancer therapeutics.

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Published

2014-12-19

Issue

Vol. 1 (2014)

Section

Review