The biological function of microRNA195 and its relationship with angiogenesis

DOI: 10.14800/rd.610

Authors

  • Jingjing Wang, Qinghai Zeng, Caihong Yi, Jin Luo, Ningning Tang, Shaohua Wang, Jia Chen, Ke Cao, Jianda Zhou

Abstract

microRNA participates in multiple biological activities by combining with target genes, degrading target mRNA or suppressing its translation which regulates the expression of genes. MicroRNA-195 is an important member of microRNA-15/161/195/424/497 family. miRNA-195 exerts its significant biological function in regulating cell cycle, apoptosis, cell metabolism, cell proliferation and metastasis by targetedly modulating MYB, CCND1, CCND3, CCNE1, E2F3, CDK6, Bcl-2, APP, BACE1, GLUT, SRC-3, Vav2, and CDC42. Recent studies have shown that miRNA-195 regulates angiogenic factors such as FGF1, VEGF and signaling pathways such as TGF-?1/ Smads and that miRNA-195 participates in the restoration of intima, tumour, the remodling of angiocarpy.

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Published

2015-11-19

Issue

Vol. 2 (2015): Supplement 1

Section

Review