RNA and DNA nanoparticles for triggering RNA interference

DOI: 10.14800/rd.724

Authors

  • Ziad El Tannir, Kirill A Afonin, Bruce A Shapiro

Abstract

Control over the delivery of different functionalities and their synchronized activation in vivo is a challenging undertaking that requires careful design and implementation. The goal of the research highlighted herein was to develop a platform allowing the simultaneous activation of multiple RNA interference pathways and other functionalities inside cells. Our team has developed several RNA, RNA/DNA and DNA/RNA nanoparticles able to successfully complete such tasks. The reported designs can potentially be used to target myriad of different diseases.

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Published

2015-11-29

Issue

Vol. 2 (2015): Supplement 1

Section

Review