The diverse requirements of ARS2 in nuclear cap-binding complex-dependent RNA processing

DOI: 10.14800/rd.1376

Authors

  • Connor O'Sullivan, Perry L Howard

Abstract

ARS2 is a stable component of the nuclear cap-binding complex (CBC) and is critical for RNA Polymerase II transcript processing. Moreover, ARS2, and its orthologue SERRATE in plants, has been implicated in having a role in most established CBC-dependent functions. This review will provide insight into the functions of ARS2/SERRATE in numerous RNA Polymerase II transcript processing events, which happen co-transcriptionally from initiation to termination, and post-transcriptionally during maturation and export into the cytoplasm. Additionally, we will discuss what is known regarding ARS2/SERRATE structure in plants and in mammals.

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Published

2017-08-02

Issue

Vol. 4 (2017)

Section

Review