Salicylic acid receptor in plants and humans

Abstract

A NAD(P)H-reductase like protein that undergoes conformational changes in the presence of salicylic acid, aspirin, and 2,6-dihydroxybenzoic acid has been purified. The protein is evolutionarily conserved and was found in plants and humans. A strong relationship between the protein conformation and temperature of plants, human neuroblastoma cell line, SK-N-SH, and mouse brain tissue has been demonstrated. These findings create a common ground for studying thermoregulation in plants and humans.