The Dynamic Dyad: Cardiac Ryanodine Receptors on the Move

Abstract

This research highlight focuses on new developments in our understanding of the structure and function of the mammalian dyad, and of the type 2 ryanodine receptor (RyR2) in particular. Recent investigations have challenged the view of dyads as static and repetitive structures with one functioning much as the next. New data has revealed that dyads have diverse molecular architectures and are dynamic structures where the organization of their RyR2 can be changed by changes in the local environment.