A Potential Role of SDF-1/CXCR4 Chemotactic Pathway in Wound Healing and Hypertrophic Scar Formation

Abstract

Fibroproliferative disorders are an ongoing clinical issue that is prevalent within society today. These disorders generally manifest themselves by an overproduction of fibrotic tissue with unknown provocation resulting in numerous detrimental defects. Cellular migration of blood-borne cells via the chemotactic pathway, consisting of stromal cell-derived factor 1 and its receptor, CXCR4, has been strongly implicated in post-burn hypertrophic scar formation. Evidence has shown this pathway has potential as a therapeutic target in the formation of hypertrophic scar and likely in other fibroproliferative disorders.