About the Publisher

About Smart Science & Technology LLC

Smart Science & Technology is a Houston publisher serving international science and technology communities with open access peer-reviewed journals covering frontier disciplines. All of the Journals published by Smart Science & Technology maintain the highest standards, with internationally-recognized editors and reviewers serving those journals.

Names and addresses of the owners of the publishing company.

Smart Science & Technology LLC was registered in Texas, United States. The owner is Xinjie Tan.

Location of corporate office.

2600 S Gessner Rd - Woodlake Plaza, Houston, TX 77063.

Principal Contact.

Tommy Xinjie TAN

Phone: 713-835-6658

Email: admin@smartscitech.com

Members of the management team, Profile and Publishing credentials.

Xinjie TAN, M.D., Ph.D.

Research Assistant Professor, Center for Nuclear Receptors and Cell Signaling, University of Houston.

Senior Neurologist, Second Hospital affiliated to Chongqing Medical University.

Dr. Tan has been engaged in scientific research since 2000. He has published a series of high-quality research papers, undertaken a number of projects funded by National Natural Science Foundation of China. During his time as research assistant professor at the University of Houston, Dr. Tan conducted research on drug development related to Eli Lilly and Company. Not only that, he also has been the editor and reviewer for many journals, such as PNAS, Cell Death & Disease, Journal of BIOLOGICAL REGULATORS & Homeostatic Agents, American Journal of Translational Research, Cellular Physiology and Biochemistry, International Journal of Medical Sciences, etc. Since 2012, Dr. Tan began to engage in related work in the field of publishing, including the publication of scientific journals, and the development of software systems for preventing academic misconduct. In addition, he also undertook the investigation commissioned by the National Research Integrity Office of the Ministry of Science and Technology of China on allegations of academic misconduct by Chinese scientific researchers. The results of his work have been written into an official guideline for Chinese journal editors by China Association for Science and Technology. In short, Dr. Tan has extensive experience from the publishing process to the monitoring and prevention of research misconduct, which help ensure the quality of both the journals and research papers published on them.

Representative Publications:

Liu X, Deng J, Li R, Tan C, Li H, Yang Z, Chen L, Chen Y, Tan X. (2019) ERβ-selective agonist alleviates inflammation in a multiple sclerosis model via regulation of MHC II in microglia. Am J Transl Res, 11(7):4411-4424.

Liu Y, Wang T, Liu X, Wen Y, Xu T, Yu X, Wei X, Ding X, Mo L, Yin M, Tan X, Chen L. (2018) Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats. J Neuroinflammation,15(1):92.

Ding X, Liu X, Tan C, Yin M, Wang T, Liu Y, Mo L, Wei X, Tan X, Deng F, Chen L. (2018) Resumption of antiplatelet therapy in patients with primary intracranial hemorrhage-benefits and risks: A meta-analysis of cohort studies. J Neurol Sci,384:133-138.

Xu T, Yu X, Ou S, Liu X, Yuan J, Tan X, Chen Y. (2017) Adherence to Antihypertensive Medications and Stroke Risk: A Dose-Response Meta-Analysis. J Am Heart Assoc, 6(7). pii: e006371.

Liu X, Ou S, Yin M, Xu T, Wang T, Liu Y, Ding X, Yu X, Yuan J, Huang H, Zhang X, Tan X, Chen L, Chen Y. (2017) N-methyl-D-aspartate receptors mediate epilepsy-induced axonal impairment and tau phosphorylation via activating glycogen synthase kinase-3β and cyclin-dependent kinase 5. Discov Med, 23(127):221-234.

Liu X, Ou S, Xu T, Liu S, Yuan J, Huang H, Qin L, Yang H, Chen L, Tan X, Chen Y. (2016) New differentially expressed genes and differential DNA methylation underlying refractory epilepsy. Oncotarget, 7(52):87402-87416.

Hao Zhou, Ye Liu, Xin-Jie Tan, Yu-Chuan Wang, Kai-Yu Liu, Yu-Xia Cui. (2015) Inhibitory effect of arsenic trioxide on neuronal migration in vitro and its potential molecular mechanism. Environ ToxicolPharmacol, 40:671-677.

Wu WF, Tan XJ, Dai YB, Krishnan V, Warner M, Gustafsson JÅ. (2013)Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis. Proc Natl AcadSci USA, 110:3543-3548.

Dai YB, Tan XJ, Wu WF, Warner M, Gustafsson JÅ. (2012) Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease. Proc Natl AcadSci USA, 109:13112-13117.

Tan XJ, Dai YB, Wu WF, Warner M, Gustafsson JÅ. (2012) Anxiety in liver X receptor β knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex. Proc Natl AcadSci USA, 109:7493-7498.

Tan XJ, Dai YB, Wu WF, Kim HJ, Barros RP, Richardson TI, Yaden BC, Warner M, McKinzie DL, Krishnan V, Gustafsson JA. (2012) Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor β ligand. Proc. Natl. Acad. Sci. USA, 109:1708-1712.

Tan XJ, Fan XT, Kim HJ, Butler R, Webb P, Warner M, Gustafsson JA. (2010) Liver X receptor β and thyroid hormone receptor α in brain cortical layering. Proc. Natl. Acad. Sci. USA, 107, 12305-12310.

Yubing DAI, M.D., Ph.D.

Research Assistant Professor, Center for Nuclear Receptors and Cell Signaling, University of Houston.

Senior Scientist, First Hospital affiliated to Chongqing Medical University.

Dr. Dai has been engaged in scientific research since 2004 and has published a large number of high-quality research papers. He has been the Deputy Director of the Editorial Office of the Journal of Receptors & Clinical Investigation for two years. He has worked as a research assistant professor at the University of Houston and has an excellent record. He has been the editor and reviewer for many journals, such as PLOS One, American Journal of Translational Research, Cellular Physiology and Biochemistry, etc. Dr. Dai has been our company's senior managing editor since 2017. In short, Dr. Dai has extensive experience in the fields of scientific research and academic publishing.

Representative Publications:

Song XY, Wu WF, Gabbi C, Dai YB, So M, Chaurasiya SP, Wang L, Warner M, Gustafsson JÅ. Retinal and optic nerve degeneration in liver X receptor β knockout mice. Proc Natl Acad Sci U S A. 2019;116(33):16507-16512.

Katreddy RR, Bollu LR, Su F, Xian N, Srivastava S, Thomas R, Dai Y, Wu B, Xu Y, Rea MA, Briggs JM, Zhang Q, Lu X, Huang G, Weihua Z. Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt. Oncogenesis. 2018;7(1):5.

Wu WF, Maneix L, Insunza J, Nalvarte I, Antonson P, Kere J, Yu NY, Tohonen V, Katayama S, Einarsdottir E, Krjutskov K, Dai YB, Huang B, Su W, Warner M, Gustafsson JÅ. Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate. Proc Natl Acad Sci U S A. 2017;114(19):E3816-E3822.

Su W, Peng J, Li S, Dai YB, Wang CJ, Xu H, Gao M, Ruan XZ, Gustafsson JÅ, Guan YF, Zhang XY. Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c. Am J Physiol Endocrinol Metab. 2017;312(4):E357-E367.

Miao YF, Su W, Dai YB, Wu WF, Huang B, Barros RP, Nguyen H, Maneix L, Guan YF, Warner M, Gustafsson JÅ. An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice. Sci Rep. 2016;6:38579.

Huang B, Butler R, Miao Y, Dai Y, Wu W, Su W, Fujii-Kuriyama Y, Warner M, Gustafsson JÅ. Dysregulation of Notch and ERα signaling in AhR-/- male mice. Proc Natl Acad Sci U S A. 2016;113(42):11883-11888.

Dai YB, Miao YF, Wu WF, Li Y, D'Errico F, Su W, Burns AR, Huang B, Maneix L, Warner M, Gustafsson JÅ. Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice. Proc Natl Acad Sci U S A. 2016;113(27):7614-9.

Song Z, Zhang X, Zhang L, Xu F, Tao X, Zhang H, Lin X, Kang L, Xiang Y, Lai X, Zhang Q, Huang K, Dai Y, Yin Y, Cao J. Progranulin Plays a Central Role in Host Defense during Sepsis by Promoting Macrophage Recruitment. Am J Respir Crit Care Med. 2016;194(10):1219-1232.

Miao Y, Wu W, Dai Y, Maneix L, Huang B, Warner M, Gustafsson JÅ. Liver X receptor β controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue. Proc Natl Acad Sci U S A. 2015;112(45):14006-11.

Li Y, Dai YB, Sun JY, Xiang Y, Yang J, Dai SY, Zhang X. Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway. J Mol Neurosci. 2016;58(1):28-38.

Cao J, Wang D, Xu F, Gong Y, Wang H, Song Z, Li D, Zhang H, Li D, Zhang L, Xia Y, Xu H, Lai X, Lin S, Zhang X, Ren G, Dai Y, Yin Y. Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. EMBO Mol Med. 2014;6(1):120-40.

Wu WF, Tan XJ, Dai YB, Krishnan V, Warner M, Gustafsson JÅ. Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2013;110(9):3543-8.

Dai YB, Tan XJ, Wu WF, Warner M, Gustafsson JÅ. Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease. Proc Natl Acad Sci U S A. 2012;109(32):13112-7.

Tan XJ, Dai YB, Wu WF, Warner M, Gustafsson JÅ. Anxiety in liver X receptor β knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex. Proc Natl Acad Sci U S A. 2012;109(19):7493-8.

Tan XJ, Dai YB, Wu WF, Kim HJ, Barros RP, Richardson TI, Yaden BC, Warner M, McKinzie DL, Krishnan V, Gustafsson JÅ. Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor β ligand. Proc Natl Acad Sci U S A. 2012;109(5):1708-12.

Xiaoxiang GUAN, M.D., Ph.D.

Professor, Nanjing Medical University, China

Visiting Scholar, MD Anderson Cancer Center, Houston

Dr. Guan is a very well-known oncologist in China. He has been engaged in scientific research since 1996 and has published more than 100 high-quality research papers. He has studied at the Breast Cancer Center of Nottingham University Hospital in the United Kingdom and the MD Anderson Cancer Center of the University of Texas in the United States for more than 2 years. He has long been engaged in clinical treatment and basic research of malignant tumors. At the same time, he has served on the editorial boards and reviewers of numerous journals, including PLOS ONE, BBRC, Cell Death & Disease, etc. He won the honorary titles of "Key Medical Talents" in Jiangsu Province, "333 Talents" in Jiangsu Province, and "Top Ten Youth Science and Technology Stars" in Jiangsu Province. He won the second prize of the Natural Science Award of the Ministry of Education in 2010, the Young Scientist Award of Jiangsu Province, the EUSOMA Research Scholar Award and the American Cancer Society Research Scholar Award. As the PI, he have over 6 projects funded by the National Natural Science Foundation of China and chaired the standardized diagnosis and treatment research project of key diseases in Jiangsu Province. In short, Dr. Guan is very familiar with the processes in the field of scientific research and journal publishing.

Representative Publications: 

Huang D, Tang L, Yang F, Jin J, Guan X. PIK3CA mutations contribute to fulvestrant resistance in ER-positive breast cancer. Am J Transl Res. 2019;11(9):6055-6065.

Xu K, Shi Y, Wang X, Chen Y, Tang L, Guan X. A novel BRCA1 germline mutation promotes triple-negative breast cancer cells progression and enhances sensitivity to DNA damage agents. Cancer Genet. 2019;239:26-32.

Li H, Chen Y, Wang X, Tang L, Guan X. T1-2N0M0 Triple-Negative Breast Cancer Treated With Breast-Conserving Therapy Has Better Survival Compared to Mastectomy: A SEER Population-Based Retrospective Analysis. Clin Breast Cancer. 2019.

Shi Y, Jin J, Wang X, Ji W, Guan X. DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. Neoplasia. 2019;21(6):533-544.

Wang Y, Zhou S, Yang F, Qi X, Wang X, Guan X, Shen C, Duma N, Vera Aguilera J, Chintakuntlawar A, Price KA, Molina JR, Pagliaro LC, Halfdanarson TR, Grothey A, Markovic SN, Nowakowski GS, Ansell SM, Wang ML. Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis. JAMA Onco. 2019;5(7):1008-1019.

Fulvestrant 500 mg Versus Exemestane in Postmenopausal Women With Metastatic Breast Cancer Resistant to Adjuvant Nonsteroidal Aromatase Inhibitors in Xie Y, Li Y, Zhang Y, Zhang S, Li W, Guan X, Zhao Y, Gong C, Hu X, Zhang J, Cao E, Wang L, Ge R, Wang B. Clinical Practice: A Multicenter Retrospective Study. Clin Breast Cancer. 2019;19(3):e452-e458.

Ji W, Shi Y, Wang X, He W, Tang L, Tian S, Jiang H, Shu Y, Guan X. Combined Androgen receptor blockade overcomes the resistance of breast cancer cells to palbociclib. Int J Biol Sci. 2019;15(3):522-532.

Qi Y, Wang X, Kong X, Zhai J, Fang Y, Guan X, Wang J. Expression signatures and roles of microRNAs in inflammatory breast cancer. Cancer Cell Int. 2019;19:23.

Shi Y, Jin J, Ji W, Guan X. Therapeutic landscape in mutational triple negative breast cancer. Mol Cancer. 2018;17(1):99.

Wang X, Shi Y, Huang D, Guan X.Emerging therapeutic modalities of PARP inhibitors in breast cancer. Cancer Treat Rev. 2018;68:62-68.

Yang F, Shen Y, Zhang W, Jin J, Huang D, Fang H, Ji W, Shi Y, Tang L, Chen W, Zhou G, Guan X. An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer. Cell Death Differ. 2018;25(12):2209-2220.

Shi Y, Yang F, Huang D, Guan X. Androgen blockade based clinical trials landscape in triple negative breast cancer. Biochim Biophys Acta Rev Cancer. 2018 ;1870(2):283-290.

Xu J, Zhang W, Tang L, Chen W, Guan X. Epithelial-mesenchymal transition induced PAI-1 is associated with prognosis of triple-negative breast cancer patients. Gene. 2018;670:7-14.

Liu YL, Wu HP, Zhou Q, Song QX, Rui JZ, Guan XX, Zhou GH, Zou BJ. Controllable extension of hairpin-structured flaps to allow low-background cascade invasive reaction for a sensitive DNA logic sensor for mutation detection. Chem Sci. 2017;9(6):1666-1673.

Jin J, Fang H, Yang F, Ji W, Guan N, Sun Z, Shi Y, Zhou G, Guan X. Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. Neoplasia. 2018;20(5):478-488.

Fang H, Jin J, Huang D, Yang F, Guan X. PAI-1 induces Src inhibitor resistance via CCL5 in HER2-positive breast cancer cells. Cancer Sci. 2018;109(6):1949-1957.

Li Y, Zhang W, Liu P, Xu Y, Tang L, Chen W, Guan X. Long non-coding RNA FENDRR inhibits cell proliferation and is associated with good prognosis in breast cancer. Onco Targets Ther. 2018;11:1403-1412.

Jin J, Sun Z, Yang F, Tang L, Chen W, Guan X. miR-19b-3p inhibits breast cancer cell proliferation and reverses saracatinib-resistance by regulating PI3K/Akt pathway. Arch Biochem Biophys. 2018;645:54-60.

Zhenzhen DONG, Ph.D.

Associate Professor, Xi'an Petroleum University, China

Ph.D., Texas A&M University

Dr. Dong graduated from Texas A&M University with a doctorate degree in 2012. She has been engaged in scientific research for more than 10 years and has published a series of high-quality papers. She is Very familiar with related work in the field of publishing. She has been an editor and reviewer for many journals, such as SPE Economics and Management and the Journal of Natural Gas Science and Engineering (JNGSE). From 2012 to 2015, she was an associate editor of the Journal of Natural Gas Science and Engineering (JNGSE). Overall, Dr. Dong is very familiar with scientific research and journal publishing.

Representative Publications:

G Lei, S Mo, Z Dong, C Wang, W Li. Theoretical and experimental study on stress-dependency of oil–water relative permeability in fractal porous media. Fractals. 2018:26(02):1840010.

Y Yang, W Li, T Zhou, Z Dong. Using Polymer Alternating Gas to Enhance Oil Recovery in Heavy Oil. IOP Conference Series: Earth and Environmental Science. 2018;113(1):012182.

W Li, Z Dong, G Lei. Integrating Embedded Discrete Fracture and Dual-Porosity, Dual-Permeability Methods to Simulate Fluid Flow in Shale Oil Reservoirs. Energies. 2017;10(10):1471.

Z Dong, SA Holditch, WJ Lee. World Recoverable Unconventional Gas Resources Assessment. Unconventional Oil and Gas Resources Handbook. 2016;53-70.

Z Dong, SA Holditch, WJ Lee. Resource Estimation for Shale Gas Reservoirs. Fundamentals of Gas Shale Reservoirs. 2015;301-323.

Z Dong, SA Holditch, WB Ayers, WJ Lee. Probabilistic Estimate of Global Coalbed-Methane Recoverable Resources. SPE Economics & Management. 2015;7(04):148-156.

Z Dong, S Holditch, D McVay. Resource evaluation for shale gas reservoirs. SPE Economics & Management. 2013;5(01):5-16.

Z Dong, S Holditch, D McVay, WB Ayers. Global unconventional gas resource assessment. SPE Economics & Management. 2012;4(04):222-234. 

Henry HWANG, IT specialist

Mr. HWANG has been our IT specialist for more than 5 years and he is very familiar with our publishing system, including XML format output, FTP setting up, etc.

Cori Wilhelm, MLIS, MSEd, Language Editor

Ms. Wilhelm is responsible for editing and proofreading the accepted manuscripts. She has published some original research papers and she is very familiar with scientific publishing.